Complications of organic solvents in synthetic drug application

Aziridinylbenzoquinone (AZQ), Acridinyl Anisidide (m-AMSA), Tenipsode Thenvlidene-Lignan-(VM-26), and PCNU are relatively new synthetic drugs believed to have a wide spectrum of antitumor activity. Preparation of these drugs for administration requires reconstitution with an organic solvent which decomposes the thermoplastic components of I.V. infusion devices and chemo-dispensing pins. The products of this decomposition may lead to cellular damage and complicate the infusion of these agents.