Jove
Visualize
Contact Us

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Self-Powered Dressing Based on a Zn-Mo Galvanic Cell for Accelerated Wound Repair.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Correction to "Conductive Microneedle Patch with Electricity-Triggered Drug Release Performance for Atopic Dermatitis Treatment".

ACS applied materials & interfaces·2026
Same author

PEDOT: PSS for Implantable and Wearable Bioelectronics: From Material Engineering and Energy Storage to Clinical Translation.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Restoration of endogenous electric fields with a glucose-powered symbiotic bioabsorbable bandage for diabetic wound healing.

Science advances·2026
Same author

A Wearable Thermoelectric Respiratory Sensing System for Quantitative Pulmonary Function Monitoring.

ACS nano·2026
Same author

An antiswelling biodegradable hydrogel reshapes electro-microenvironment to drive endogenous neuroregeneration after brain defect.

Science advances·2026
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 30, 2025

Interlinked Macroporous 3D Scaffolds from Microgel Rods
07:32

Interlinked Macroporous 3D Scaffolds from Microgel Rods

Published on: June 16, 2022

2.2K

Hierarchical hydrogel scaffolds with a clustered and oriented structure.

Jian Cheng1,2, Jiangtao Xue2,3, Yuan Yang2

  • 1Center on Nanoenergy Research, School of Physical Science and Technology, Guangxi University, Nanning 530004, China. zli@binn.cas.cn.

Journal of Materials Chemistry. B
|May 12, 2023
PubMed
Summary

Polyvinyl alcohol/alginate hydrogel scaffolds with a clustered, oriented structure were developed for tissue engineering. These anisotropic scaffolds guide cell alignment, enhancing tissue regeneration and offering tunable mechanical properties.

More Related Videos

Construction of Modular Hydrogel Sheets for Micropatterned Macro-scaled 3D Cellular Architecture
10:55

Construction of Modular Hydrogel Sheets for Micropatterned Macro-scaled 3D Cellular Architecture

Published on: January 11, 2016

10.3K
Gelatin Methacryloyl Granular Hydrogel Scaffolds: High-throughput Microgel Fabrication, Lyophilization, Chemical Assembly, and 3D Bioprinting
10:36

Gelatin Methacryloyl Granular Hydrogel Scaffolds: High-throughput Microgel Fabrication, Lyophilization, Chemical Assembly, and 3D Bioprinting

Published on: December 9, 2022

7.0K

Related Experiment Videos

Last Updated: Jul 30, 2025

Interlinked Macroporous 3D Scaffolds from Microgel Rods
07:32

Interlinked Macroporous 3D Scaffolds from Microgel Rods

Published on: June 16, 2022

2.2K
Construction of Modular Hydrogel Sheets for Micropatterned Macro-scaled 3D Cellular Architecture
10:55

Construction of Modular Hydrogel Sheets for Micropatterned Macro-scaled 3D Cellular Architecture

Published on: January 11, 2016

10.3K
Gelatin Methacryloyl Granular Hydrogel Scaffolds: High-throughput Microgel Fabrication, Lyophilization, Chemical Assembly, and 3D Bioprinting
10:36

Gelatin Methacryloyl Granular Hydrogel Scaffolds: High-throughput Microgel Fabrication, Lyophilization, Chemical Assembly, and 3D Bioprinting

Published on: December 9, 2022

7.0K

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Hydrogel scaffolds are crucial in tissue engineering due to their biocompatibility and hydrophilic nature.
  • Anisotropic scaffolds, mimicking native tissue structure, are essential for effective tissue regeneration and organoid development.

Purpose of the Study:

  • To develop hierarchical, anisotropic polyvinyl alcohol (PVA)/alginate hydrogel scaffolds.
  • To investigate the ability of these scaffolds to guide cell alignment and enhance tissue regeneration.

Main Methods:

  • A combination of directional freezing and drying under stretching was employed to create clustered and oriented hydrogel microstructures.
  • The mechanical properties (modulus) of the hydrogel scaffolds were adjusted to match various tissue types.

Main Results:

  • The developed hydrogel scaffolds exhibited tunable mechanical properties ranging from 50 kPa to 20 MPa.
  • The anisotropic, clustered structure effectively guided the alignment and orientation of fibroblasts and chondrocytes in vitro.
  • The scaffolds demonstrated potential for promoting tissue regeneration.

Conclusions:

  • This study presents a novel method for fabricating hierarchical and anisotropic hydrogel scaffolds.
  • The PVA/alginate hydrogels show significant promise for applications in tissue regeneration and the development of tissue equivalents.