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Updated: Jul 30, 2025

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies
Published on: July 29, 2007
Levamisole derivatives as immune modulators for the treatment of amyotrophic lateral sclerosis (ALS)
Simon Dp Baugh1, Jessica R Morrice2, Allen B Reitz1
1Fox Chase Therapeutics Discovery, Inc., Doylestown, PA 18902, USA.
Abstract:
Aim: To discover derivatives of the anthelmintic drug levamisole, which has been reported to possess immune-modulatory properties, as treatments for amyotrophic lateral sclerosis (ALS), which has been suggested to be in part an autoimmune disease. Results: We have synthesized ten analogs of the racemic version of levamisole, tetramisole, as well as eleven analogs on a related system. All of the analogs have been tested for their ability to affect the response of five ALS-relevant cytokines. Conclusion: We have discovered a number of interesting derivatives that have encouraging cytokine response data and good metabolic stability, with the potential to have a positive impact on ALS either as single agents, or in combination.
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