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Published on: June 23, 2019
Imidazo[4,5-b]Pyridines: From Kinase Inhibitors to more Diversified Biological Properties
Karim Jarmoni1,2, Khalid Misbahi2, Vincent Ferrières1
1Univ Rennes, Ecole Nationale Supérieure de Chimie de Rennes, CNRS, UMR 6226 - ISCR, Rennes, 35000, France.
Abstract:
Imidazo[4,5-b]pyridines are amongst the oldest known heteroaromatic derivatives. Their structural similarity with purine basis has however aroused the curiosity of biologists and resulted in the developments of innovative bioactive compounds. This review thus firstly describes the main synthetic ways currently used to produce imidazo[ 4,5-b]pyridine derivatives, and secondly gives examples of their potential, especially focusing on protein inhibition abilities, thus opening the way to applications as anti-cancer or antimicrobial agents.
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