NET-Works paediatric obesity prevention trial: 66month outcomes

Simone A French1, Alicia S Kunin-Batson2, Nancy E Sherwood1

  • 1Division of Epidemiology & Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota, USA.

Pediatric Obesity
|May 12, 2023
PubMed

Insights

The NET-Works trial found a 3-year obesity prevention intervention did not significantly reduce overall child BMI at 66 months. However, it slowed BMI gain in overweight and Hispanic children, suggesting targeted early interventions are effective.

Area of Science:

  • Pediatric obesity prevention
  • Public health interventions
  • Childhood cardiometabolic health

Background:

  • The NET-Works trial (2012-2018) evaluated a multicomponent obesity prevention intervention for children aged 2-4 years.
  • The study aimed to assess long-term effects on body mass index (BMI) and related factors.

Purpose of the Study:

  • To examine the 66-month treatment effects of a multicomponent obesity prevention intervention on child BMI and other health outcomes.
  • To identify potential subgroup effects within the intervention and control groups.

Main Methods:

  • Randomized controlled trial involving 534 children and their caregivers.
  • Follow-up measurements at 66 months included child BMI, physical activity, diet, and cardiometabolic risk factors for 338 parent-child dyads.

Main Results:

  • No significant overall treatment effect on child BMI was observed at 66 months (Effect = -0.38).
  • The intervention significantly slowed BMI gain in children who were overweight at baseline (Effect = -1.28).
  • Hispanic children in the intervention group showed significantly less BMI gain compared to the control group (Effect = -1.04).

Conclusions:

  • Community-based, multicomponent interventions may effectively reduce excess weight gain in specific high-risk subgroups.
  • The NET-Works intervention demonstrated effectiveness in slowing BMI gain among overweight and Hispanic children at 66 months post-randomization.
Abstract

Related Concept Videos

Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
556
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
3.1K
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
6.9K
Parentral Nutrition: Centeral and Peripheral Parental Nutrition01:27

Parentral Nutrition: Centeral and Peripheral Parental Nutrition

Parenteral Nutrition (PN) delivers essential nutrients directly into the bloodstream, bypassing the digestive system. It is commonly used for individuals with severe digestive disorders or conditions that prevent normal nutrient absorption.
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
237
Community Based Intervention01:30

Community Based Intervention

Community-based interventions in mental health represent a paradigm shift from institution-centered care to treatments embedded within the fabric of local communities. By prioritizing inclusion and leveraging existing societal structures, this approach fosters a supportive environment conducive to addressing mental health challenges while promoting individual dignity and agency.
Foundations of Community Mental Health Programs
Central to the success of community-based interventions is the...
67
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
119