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Pre-eclampsia: does cardiac function differ in HIV-positive and -negative women?

Raeesa Bhorat1, Ismail Bhorat2, Olive P Khaliq3

  • 1Department of Cardiology, School of Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa.

Cardiovascular Journal of Africa
|May 12, 2023
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Summary

This review examines how pre-eclampsia and HIV infection impact cardiac function, noting their combined effects and potential bidirectional pathophysiology. Further research is crucial for developing new treatments for these interrelated cardiovascular health challenges.

Keywords:
ARTHIVcardiovascular diseasepre‐eclampsia

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Area of Science:

  • Cardiology
  • Infectious Diseases
  • Obstetrics

Background:

  • Cardiovascular diseases complicate pregnancies affected by HIV and pre-eclampsia.
  • Pre-eclampsia is linked to both systolic and diastolic cardiac dysfunction.
  • A dual, bidirectional pathophysiology may link placental factors, cardiac function, and pre-eclampsia risk.

Purpose of the Study:

  • To establish the impact of pre-eclampsia and HIV infection on cardiac function.
  • To explore the interrelated pathophysiology of cardiovascular disease, HIV, and pre-eclampsia.
  • To identify areas for future research and therapeutic interventions.

Main Methods:

  • Literature review synthesizing existing research on pre-eclampsia, HIV, and cardiac function.
  • Analysis of pathophysiological links between cardiovascular disease, HIV, and pre-eclampsia.
  • Identification of the influence of antiretroviral therapy on cardiac function.

Main Results:

  • Both pre-eclampsia and HIV infection contribute to cardiac dysfunction.
  • Antiretroviral therapy also impacts cardiac function.
  • The interplay between these conditions presents significant cardiovascular challenges.

Conclusions:

  • Pre-eclampsia and HIV infection significantly affect cardiac function.
  • Understanding the bidirectional pathophysiology is key for future interventions.
  • Further research is needed to develop novel therapeutic strategies for these complex conditions.