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Updated: Jul 30, 2025

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring
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Oxidized LDL receptors: a recent update.

Mohd Azeem Khan1, Irshad Mohammad1, Sohom Banerjee1

  • 1Membrane Protein Biology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India.

Current Opinion in Lipidology
|May 12, 2023
PubMed
Summary

Oxidized LDL (oxLDL) drives atherosclerosis. Targeting the oxLDL receptor LOX-1 offers potential for treating cardiovascular diseases and using soluble LOX-1 as a diagnostic biomarker.

Area of Science:

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  • Cardiovascular Research
  • Molecular Biology
  • Biochemistry

Background:

  • Oxidized low-density lipoprotein (oxLDL) is a key factor in atherosclerosis.
  • Understanding oxLDL receptors is crucial for studying plaque formation and progression.

Conclusions:

  • The oxLDL-LOX-1 pathway is central to atherogenesis.
  • LOX-1 presents a viable target for novel cardiovascular therapies.
  • Soluble LOX-1 can serve as a valuable biomarker.