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Related Experiment Videos

Estrogen use and cardiovascular disease.

B E Henderson, R K Ross, A Paganini-Hill

    American Journal of Obstetrics and Gynecology
    |June 1, 1986
    PubMed
    Summary

    Postmenopausal estrogen replacement therapy may reduce mortality from all causes and acute myocardial infarction. Even small reductions in coronary artery disease mortality significantly impact the overall risk-benefit profile of estrogen use.

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    Area of Science:

    • Cardiovascular epidemiology
    • Postmenopausal health

    Background:

    • Epidemiologic studies suggest postmenopausal estrogen use offers protection against coronary artery disease.
    • Estrogen replacement therapy (ERT) is widely used by postmenopausal women.

    Purpose of the Study:

    • To evaluate the impact of ERT on all-cause mortality and acute myocardial infarction (AMI) mortality.
    • To assess the risk-benefit ratio of ERT in postmenopausal women.

    Main Methods:

    • Comparison of mortality rates between ERT users and never-users.
    • Analysis of epidemiologic data from case-control and cohort studies.

    Main Results:

    • Reduced all-cause mortality rates observed in ERT users compared to never-users.
    • Lower mortality rates for AMI found among ERT users.

    Conclusions:

    • Postmenopausal estrogen use is associated with reduced mortality from all causes and AMI.
    • Even minor decreases in coronary artery disease mortality substantially influence the risk-benefit assessment of ERT.

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