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Chorionic villus sampling: experience of the first 1000 cases
American Journal of Obstetrics and Gynecology
|June 1, 1986
Summary
Chorionic villus sampling (CVS) is a safe first-trimester prenatal test for genetic disorders. Performed between the ninth and eleventh weeks, it has a low spontaneous abortion rate of 3.8%.
Area of Science:
- Perinatology
- Medical Genetics
- Obstetrics
Background:
- Chorionic villus sampling (CVS) is a common first-trimester procedure.
- It is used for prenatal diagnosis of genetic disorders.
- CVS is an alternative to second-trimester amniocentesis.
Purpose of the Study:
- To evaluate the safety and reliability of chorionic villus sampling.
- To assess complication rates associated with CVS.
- To determine the optimal gestational age for CVS procedures.
Main Methods:
- A review of 1000 consecutive chorionic villus sampling cases.
- Analysis of complication rates including spontaneous abortion, chorioamnionitis, and oligohydramnios.
- Assessment of discrepancies between villus karyotype and fetal karyotype.
Main Results:
- Spontaneous abortion rate was 3.8% when CVS was performed between the ninth and eleventh menstrual weeks.
- Later complications included chorioamnionitis (0.6%) and oligohydramnios (0.8%).
- Karyotype discrepancies occurred in 1.7% of cases, often due to villus mosaicism.
Conclusions:
- Chorionic villus sampling is a safe and reliable first-trimester procedure for prenatal genetic diagnosis.
- The optimal timing for CVS to minimize spontaneous abortion is between the ninth and eleventh weeks.
- Further research is needed before widespread adoption as an amniocentesis alternative.