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07:37
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
237
Long non-coding RNAs and rheumatoid arthritis: Pathogenesis and clinical implications
Ola Elazazy1, Heba M Midan1, Reem K Shahin1
1Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr, Cairo 11829, Egypt.
Pathology, Research and Practice
|May 12, 2023
Summary
Long non-coding RNAs (lncRNAs) show abnormal expression in rheumatoid arthritis (RA), offering potential as diagnostic and therapeutic targets. This review explores lncRNAs in RA pathogenesis and clinical implications for future treatments.
Area of Science:
- Molecular Biology
- Immunology
- Genetics
Background:
- Rheumatoid arthritis (RA) is a systemic autoimmune disease causing joint inflammation and damage.
- Gene expression dysregulation is implicated in RA pathogenesis.
- Long non-coding RNAs (lncRNAs) are emerging regulators of gene expression.
Purpose of the Study:
- To review the role of lncRNAs in rheumatoid arthritis.
- To highlight lncRNAs as potential biomarkers for RA diagnosis and prognosis.
- To discuss lncRNAs as therapeutic targets for RA treatment.
Main Methods:
- Literature review of studies on lncRNAs and RA.
- Analysis of lncRNA expression patterns in RA patients.
- Examination of the functional mechanisms of lncRNAs in RA pathogenesis.
Main Results:
- Abnormal expression of numerous lncRNAs is consistently observed in RA patients.
- Specific lncRNAs are associated with disease activity and severity in RA.
- lncRNAs influence RA pathogenesis through epigenetic, transcriptional, and post-transcriptional regulation.
Conclusions:
- lncRNAs represent promising biomarkers for RA diagnosis, prognosis, and monitoring.
- Targeting specific lncRNAs offers a potential therapeutic strategy for RA.
- Further research into lncRNA functions can uncover novel treatment avenues for RA.
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