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Updated: Jul 30, 2025

Electroporation of Plasmid DNA into Mouse Skeletal Muscle
Published on: April 6, 2022
Muscle fusogens go viral for gene delivery to skeletal muscle
1Molecular Biology Institute, Department of Microbiology, Immunology and Molecular Genetics, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Abstract:
Viruses and multinucleated cells rely on fusogens to facilitate the fusion of their membranes. In this issue of Cell, Millay and colleagues demonstrate that replacing viral fusogens with mammalian skeletal muscle fusogens leads to the specific transduction of skeletal muscle and the ability to deliver gene therapy constructs in a therapeutically relevant muscle disease.
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