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Indeterminate Thyroid Nodules and Advances in Molecular Pathology
Brendan Belovarac1, Fang Zhou1, Jake Sharma1
1NYU Langone Health, Department of Pathology, 560 First Avenue 4th Floor, New York NY 10016, USA.
Seminars in Diagnostic Pathology
|May 12, 2023
Summary
Molecular testing aids in diagnosing indeterminate thyroid lesions. This review details available tests and common genetic drivers in papillary thyroid carcinoma (PTC) and follicular lesions to guide clinical management.
Area of Science:
- Endocrinology
- Molecular Pathology
- Oncology
Background:
- Thyroid cytology for indeterminate lesions is enhanced by molecular testing.
- Three commercial molecular tests offer varying genetic detail for thyroid samples.
Purpose of the Study:
- To describe available molecular tests for indeterminate thyroid lesions.
- To outline common molecular drivers in papillary thyroid carcinoma (PTC) and follicular lesions.
- To aid pathologists and clinicians in interpreting molecular test results for improved patient management.
Main Methods:
- Review of commercial molecular tests for thyroid nodules.
- Analysis of genetic alterations associated with PTC and follicular patterned lesions.
Main Results:
- Detailed descriptions of three commercial molecular diagnostic tests.
- Identification of key molecular drivers in common thyroid cancer subtypes.
Conclusions:
- Understanding molecular test details and genetic drivers is crucial for managing cytologically indeterminate thyroid lesions.
- Integration of molecular testing results can refine clinical decision-making for thyroid nodules.
