Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Exosomes01:36

Overview of Exosomes

2.8K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
2.8K
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

2.3K
Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
2.3K
The Tumor Microenvironment02:17

The Tumor Microenvironment

6.7K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.7K
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

5.0K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
5.0K
Metastasis02:30

Metastasis

5.6K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.6K
What is Cell Signaling?02:03

What is Cell Signaling?

119.5K
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
119.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

STIM/Orai-Mediated Store-Operated Ca<sup>2+</sup> Entry in the Pathogenesis of Fibrosis: Mechanisms and Therapeutic Opportunities.

Cells·2026
Same author

Inter-membrane control of junctional InsP<sub>3</sub> receptors by PIP<sub>2</sub>.

Trends in cell biology·2024
Same author

Podocyte-Specific Expression of the Stress Response Protein REDD1 Is Necessary for Diabetes-Induced Podocytopenia.

Diabetes·2024
Same author

An apical Phe-His pair defines the Orai1-coupling site and its occlusion within STIM1.

Nature communications·2023
Same author

Macrophage Function Modulated by tPA Signaling in Mouse Experimental Kidney Disease Models.

International journal of molecular sciences·2023
Same author

Identifying 2PHDO as a SOCE Inhibitor from Chinese Herbal Extracts

Current pharmaceutical biotechnology·2023

Related Experiment Video

Updated: Jul 30, 2025

An Enrichment Method for Small Extracellular Vesicles Derived from Liver Cancer Tissue
10:33

An Enrichment Method for Small Extracellular Vesicles Derived from Liver Cancer Tissue

Published on: February 3, 2023

1.3K

Cell-Cell Communication and Extracellular Vesicles in Cancer.

Ling Lin1, Yandong Zhou2, Kebin Hu1,2

  • 1Department of Medicine, Penn State University College of Medicine, Hershey, PA 17033, USA.

Cancers
|May 13, 2023
PubMed
Summary

Cell-cell communication is vital for cell functions like growth and survival, maintaining tissue structure. Understanding these signals is key to tissue engineering and regenerative medicine.

More Related Videos

LINE-1 Methylation Analysis in Mesenchymal Stem Cells Treated with Osteosarcoma-Derived Extracellular Vesicles
12:18

LINE-1 Methylation Analysis in Mesenchymal Stem Cells Treated with Osteosarcoma-Derived Extracellular Vesicles

Published on: February 1, 2020

5.8K
Extraction of Extracellular Vesicles from Whole Tissue
09:03

Extraction of Extracellular Vesicles from Whole Tissue

Published on: February 7, 2019

15.1K

Related Experiment Videos

Last Updated: Jul 30, 2025

An Enrichment Method for Small Extracellular Vesicles Derived from Liver Cancer Tissue
10:33

An Enrichment Method for Small Extracellular Vesicles Derived from Liver Cancer Tissue

Published on: February 3, 2023

1.3K
LINE-1 Methylation Analysis in Mesenchymal Stem Cells Treated with Osteosarcoma-Derived Extracellular Vesicles
12:18

LINE-1 Methylation Analysis in Mesenchymal Stem Cells Treated with Osteosarcoma-Derived Extracellular Vesicles

Published on: February 1, 2020

5.8K
Extraction of Extracellular Vesicles from Whole Tissue
09:03

Extraction of Extracellular Vesicles from Whole Tissue

Published on: February 7, 2019

15.1K

Area of Science:

  • Cell Biology
  • Biochemistry
  • Tissue Engineering

Background:

  • Cell-cell communication governs essential biological processes including proliferation, survival, differentiation, and transdifferentiation.
  • Direct cell contact and indirect signaling pathways are fundamental mechanisms for intercellular information exchange.
  • Maintaining tissue integrity and a stable cellular environment relies heavily on effective cell-cell communication.

Discussion:

  • Disruptions in cell-cell communication can lead to various pathologies and developmental abnormalities.
  • Investigating the molecular mechanisms underlying cell-cell communication provides insights into disease pathogenesis.
  • The study of cell-cell communication is crucial for developing targeted therapeutic strategies.

Key Insights:

  • Cell-cell communication is indispensable for coordinating cellular activities within multicellular organisms.
  • Diverse signaling modalities ensure precise regulation of cellular behavior and tissue homeostasis.
  • Understanding these intricate communication networks is paramount for advancing biological and medical sciences.

Outlook:

  • Future research will focus on deciphering complex signaling networks and their roles in health and disease.
  • Therapeutic interventions targeting cell-cell communication hold promise for treating a range of conditions.
  • Advancements in imaging and molecular tools will further illuminate the dynamics of cell-cell interactions.