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The miR-183 Cluster: Biogenesis, Functions, and Cell Communication via Exosomes in Cancer

Shuhui Li1, Wei Meng1, Ziyi Guo1

  • 1Lab for Noncoding RNA & Cancer, School of Life Sciences, Shanghai University, Shanghai 200444, China.

Cells
|May 13, 2023
PubMed

Insights

The miR-183 cluster, including miR-183, miR-96, and miR-182, promotes cancer development. This microRNA cluster, found in exosomes, offers a promising new target for effective cancer therapy strategies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • MicroRNAs (miRNAs) are crucial regulators of gene expression and are implicated in cancer development.
  • The miR-183 cluster (miR-183, miR-96, miR-182) is a polycistronic miRNA cluster frequently overexpressed in various cancers.
  • Exosomes, extracellular vesicles, mediate intercellular communication and influence the tumor microenvironment.

Purpose of the Study:

  • To summarize the biogenesis and functions of the miR-183 cluster in prevalent cancers.
  • To explore the role of the miR-183 cluster within exosomes in tumor progression.
  • To discuss the potential of the miR-183 cluster as a therapeutic target for cancer treatment.

Main Methods:

  • Literature review and synthesis of existing research on the miR-183 cluster.
  • Analysis of studies investigating miRNA biogenesis and exosomal miRNA functions.
  • Evaluation of preclinical and clinical data related to miR-183 cluster targeting.

Main Results:

  • The miR-183 cluster promotes cancer development via diverse molecular pathways.
  • Exosomes facilitate the transport and function of the miR-183 cluster, influencing tumor microenvironment.
  • The miR-183 cluster interacts with other non-coding RNAs, contributing to cancer complexity.

Conclusions:

  • The miR-183 cluster is a significant driver of oncogenesis across multiple cancer types.
  • Targeting the miR-183 cluster, particularly its exosomal form, presents a novel therapeutic avenue.
  • Further research into the miR-183 cluster could lead to innovative cancer treatment strategies.
Keywords:
cancerexosomemiR-183 clusternoncoding RNAs

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