Vascularisation in Deep Endometriosis: A Systematic Review with Narrative Outcomes.
Simon G Powell1,2,3, Priyanka Sharma4, Samuel Masterson4
1Department of Women's and Children's Health, Institute of Life Course and Medical Science, University of Liverpool, Liverpool L8 7SS, UK.
Cells
|May 13, 2023
Summary
Deep endometriosis (DE) exhibits abnormal vascularization, characterized by increased microvessel density and specific growth factors. This finding highlights potential therapeutic targets for managing DE.
Area of Science:
- Gynecology
- Pathophysiology
- Vascular Biology
Background:
- Deep endometriosis (DE) is the most severe form of endometriosis, involving tissue infiltration.
- Abnormal vascularization is a known factor in endometriosis development.
- Understanding vascularization's role in DE pathogenesis is crucial.
Conclusions:
- Abnormal vascularization is intrinsically linked to the pathogenesis of deep endometriosis.
- Targeting vascularization pathways presents a promising strategy for DE medical management.
Related Concept Videos
Varicose Veins II: Diagnostic Studies and Interprofessional Care
19
Varicose veins, or varicosities, develop when the valves in the veins, which control blood flow, weaken or damage. It causes blood to pool and the veins to enlarge. Understanding the clinical manifestations, diagnostic approaches, and management options for varicose veins is crucial for effective treatment and relief.Clinical manifestationsClinical manifestations of varicose veins include a heavy, achy feeling or pain after prolonged standing or sitting. This discomfort can often be relieved by...
19
Histology of the Uterus
1.6K
The uterine wall consists of three histological layers: the perimetrium, myometrium, and endometrium. The outermost perimetrium is a thin, serous membrane connected with the broad ligament on the sides, which helps anchor the uterus in the pelvic cavity. The thickest layer, myometrium, is mainly made up of smooth muscle tissue bundles. Its contractions are vital in facilitating the expulsion of the uterine lining, fetus, and placenta during menstruation and childbirth.
The endometrium is the...
The endometrium is the...
1.6K


