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The Role of Polo-Like Kinase 1 in Regulating the Forkhead Box Family Transcription Factors

Xavier T R Moore1, Lilia Gheghiani2, Zheng Fu3

  • 1Department of Biology, Virginia Commonwealth University, Richmond, VA 23284, USA.

Cells
|May 13, 2023
PubMed

Insights

Polo-like kinase 1 (PLK1) regulates FOX transcription factors (TFs) involved in cancer. Targeting PLK1 and FOX TFs offers potential cancer therapies by disrupting oncogenic signaling networks.

Area of Science:

  • Molecular Biology
  • Cancer Biology
  • Biochemistry

Background:

  • Polo-like kinase 1 (PLK1) is a key regulator of numerous cellular processes, including mitosis and DNA damage response.
  • PLK1 phosphorylates over 600 substrates, impacting diverse biological functions.
  • Members of the FOX transcription factor (TF) family are among the critical targets of PLK1.

Purpose of the Study:

  • To review the regulation of FOX TFs by PLK1.
  • To highlight the impact of PLK1 on FOX TF activity and stability.
  • To discuss the prognostic and therapeutic implications of targeting PLK1-regulated FOX TFs in cancer.

Main Methods:

  • Literature review of studies on PLK1, FOX TFs, and cancer.
  • Analysis of existing data on PLK1-mediated regulation of FOX TF function.
  • Synthesis of information regarding the clinical significance and therapeutic strategies.

Main Results:

  • PLK1 modulates the activity and stability of oncogenic (FOXM1, FOXK1) and homeostasis-maintaining (FOXO1, FOXO3) FOX TFs.
  • FOXM1 and FOXK1 promote cancer progression, while FOXO1 and FOXO3 are involved in cellular homeostasis.
  • Dysregulation of PLK1 and FOX TFs has significant prognostic and clinical relevance in human cancers.

Conclusions:

  • PLK1 plays a crucial role in regulating FOX TFs, impacting cancer development and progression.
  • Targeting the PLK1-FOX TF signaling network presents a promising therapeutic strategy for various human cancers.
  • Further research into these interactions could lead to novel cancer treatments.
Keywords:
FOX familyoncogenetargeted therapytranscription factortumor suppressor

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