A Patient with Synchronous Gallbladder and Bone Plasmacytoma.

Area of Science:

• Oncology
• Pathology

Background:

• Multiple myeloma (MM) is a common bone tumor; extramedullary plasmacytoma (EMP) is rare, typically in the head/neck.
• Gastrointestinal and gallbladder EMP are exceedingly rare, often mimicking gallstone disease.

Purpose of the Study:

• To present a rare case of plasmablastic extramedullary plasmacytoma (PE-EMP) of the gallbladder.
• To discuss the diagnostic, therapeutic, and prognostic challenges associated with EMPs, particularly the plasmablastic subtype.

Main Methods:

• Case report of a 61-year-old asymptomatic patient diagnosed with gallbladder EMP.
• Utilized abdominal ultrasound (US), magnetic resonance imaging (MRI), and fluorodeoxyglucose positron emission computed tomography (FDG PET-CT).

Main Results:

• Unexpectedly diagnosed PE-EMP in the gallbladder of an asymptomatic patient.
• Concurrent bone plasmacytoma identified in the femur.
• Patient is undergoing chemotherapy and preparation for autologous stem cell transplantation.

Conclusions:

• PE-EMP presents unique diagnostic and management challenges.
• Distinguishing plasmablastic subtype from other EMPs is crucial for effective treatment.
• Early detection and tailored therapy are key for improving outcomes in rare plasma cell neoplasms.