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Updated: Jul 30, 2025

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Palladium-Catalyzed Synthesis of Cyclopropylthiophenes and Their Derivatization
Tomas Paškevičius1, Ringailė Lapinskaitė1, Sigitas Stončius1
1Department of Organic Chemistry, Center for Physical Sciences and Technology (FTMC), Akademijos g. 7, LT-08412 Vilnius, Lithuania.
Abstract:
The cyclopropylthiophene moiety has attracted the attention of the scientific community for its potential pharmaceutical applications. However, synthesis of the compounds containing this framework remains challenging, has rarely been reported and remains unresolved. Here we provide optimized syntheses for cyclopropylthiophenes and their derivatives, containing carbonyl, acetyl, carboxylic acid, methyl carboxylate, nitrile, bromide and sulfonyl chloride moieties.
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