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Radiolabeled Liposomes for Nuclear Imaging Probes.

Ho Ying Low1, Chang-Tong Yang1,2, Bin Xia3

  • 1Department of Nuclear Medicine and Molecular Imaging, Radiological Sciences Division, Singapore General Hospital, Outram Road, Singapore 169608, Singapore.

Molecules (Basel, Switzerland)
|May 13, 2023
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Summary

Liposomal radiotracers offer enhanced stability and circulation for nuclear imaging probes. This review details recent advancements in liposomal SPECT and PET imaging probes for disease diagnostics and cancer theranostics.

Keywords:
liposomesnuclear imaging probesradiolabelingradiopharmaceuticaltheranostics

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Area of Science:

  • Nuclear medicine
  • Nanotechnology
  • Radiopharmaceutical chemistry

Background:

  • Quantitative nuclear imaging is crucial for disease diagnosis and cancer theranostics.
  • Current radiotracers are typically small molecules, limiting their in vivo performance.
  • Liposomes are emerging as advanced carriers for radiotracers, offering improved properties.

Purpose of the Study:

  • To provide a comprehensive overview of liposomal radiotracers for nuclear imaging.
  • To summarize recent developments in liposomal SPECT and PET imaging probes.
  • To highlight the advantages of liposomes in radiopharmaceutical applications.

Main Methods:

  • Review of recently published literature on liposomal SPECT and PET imaging probes.
  • Analysis of physicochemical properties and structural characteristics of liposomes.
  • Summary of radiolabeling methods and synthesis strategies for liposomal tracers.

Main Results:

  • Liposomes exhibit favorable long circulation and stability as radiopharmaceuticals.
  • Various radiolabeling methods enable biocompatible and targeted liposomal probes.
  • Radiolabeled liposomes facilitate in vivo biodistribution and targeting studies.

Conclusions:

  • Liposomal radiotracers represent a promising advancement in nuclear imaging.
  • These novel probes offer significant advantages for clinical applications in diagnostics and theranostics.
  • Further development of liposomal probes is expected to enhance imaging capabilities.