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[Volatile anesthetics and tricyclic antidepressives. A case study]
Der Anaesthesist
|March 1, 1986
Summary
Tricyclic antidepressants (TAD) may increase anesthesia risk. A case study found a volunteer on amitriptyline (TAD) experienced tachycardia during anesthesia, which resolved after discontinuing TAD.
Area of Science:
- Anesthesiology
- Pharmacology
Context:
- Tricyclic antidepressants (TAD) are widely used for depression.
- Interactions between anesthetics and TAD are documented.
- This case report explores potential anesthesia risks in patients on chronic TAD medication.
Purpose:
- To investigate the influence of volatile anesthetics on the human electroencephalogram.
- To report an incidental finding of tachycardia during anesthesia in a healthy volunteer.
- To discuss the potential interaction between amitriptyline and volatile anesthetics.
Summary:
- A healthy volunteer on amitriptyline (TAD) developed tachycardia during halothane, enflurane, and isoflurane anesthesia.
- This tachycardia resolved upon discontinuation of amitriptyline and repeat anesthesia.
- This suggests a potential interaction between amitriptyline and volatile anesthetics.
Impact:
- Highlights a potential increased risk of anesthesia in patients taking tricyclic antidepressants.
- Suggests careful consideration of anesthetic choices and patient history in those on TAD.
- Underscores the importance of patient medication history in perioperative care.