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Updated: Jul 30, 2025
09:02
Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
Published on: November 26, 2018
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Do GWAS-Identified Risk Variants for Chronic Lymphocytic Leukemia Influence Overall Patient Survival and Disease
Antonio José Cabrera-Serrano1,2, José Manuel Sánchez-Maldonado1,2, Rob Ter Horst3
1Genomic Oncology Area, GENYO, Centre for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS, 18016 Granada, Spain.
International Journal of Molecular Sciences
|May 13, 2023
Summary
Genetic risk variants for chronic lymphocytic leukemia (CLL) do not significantly predict disease progression or patient survival. This study found no strong associations between identified single nucleotide polymorphisms (SNPs) and outcomes in CLL patients.
Area of Science:
- Genetics
- Oncology
- Epidemiology
Background:
- Chronic lymphocytic leukemia (CLL) is the most prevalent leukemia in adults globally.
- Genome-wide association studies (GWAS) have identified germline genetic variants linked to CLL susceptibility.
- The predictive value of these GWAS-identified risk variants for CLL progression and survival is largely unknown.
Conclusions:
- Germline genetic susceptibility variants identified through GWAS do not appear to significantly impact overall survival in CLL patients.
- These variants also demonstrate a limited ability to predict disease progression or time to first treatment in CLL.
- Current CLL susceptibility variants may not serve as reliable biomarkers for predicting clinical outcomes in affected individuals.
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