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Cell Therapy as Target Therapy against Colon Cancer Stem Cells

Elsa N Garza Treviño1, Adriana G Quiroz Reyes1, Juan Antonio Rojas Murillo1

  • 1Laboratorio de Terapia Celular, Departamento de Bioquímica y Medicina Molecular, Facultad de Medicina, Universidad Autónoma de Nuevo León, Av. Dr. José Eleuterio González 235, Monterrey 64460, Nuevo León, Mexico.

International Journal of Molecular Sciences
|May 13, 2023
PubMed

Insights

Targeting cancer stem cells (CSCs) with cellular immunotherapy shows promise for treating colorectal cancer (CRC). This approach aims to eliminate tumor recurrence and therapy resistance by leveraging immune cells to target CSCs.

Area of Science:

  • Oncology
  • Immunology
  • Cell Biology

Background:

  • Cancer stem cells (CSCs) drive tumor recurrence, metastasis, and resistance to conventional therapies.
  • Targeting CSCs is crucial for eradicating tumors and preventing relapse.
  • Immune cells are increasingly recognized for their role in regulating CSCs.

Purpose of the Study:

  • To review cellular immunotherapy strategies for targeting CSCs in colorectal cancer (CRC).
  • To summarize CRC molecular profiles amenable to CSC-targeted therapy.
  • To discuss vehicles for cell therapy against CSCs and challenges in late-stage CRC treatment.

Main Methods:

  • Literature review of cellular immunotherapy in CRC.
  • Analysis of CSC properties and their regulation by immune cells.
  • Examination of cell therapy vehicles and treatment combinations.

Main Results:

  • Cellular immunotherapies (T cells, NK cells, macrophages, stem cells) show potential for targeting CSCs in CRC.
  • Specific CRC molecular profiles may benefit from these targeted therapies.
  • Combination strategies with conventional treatments are being explored for advanced CRC.

Conclusions:

  • Cellular immunotherapy offers a promising strategy for selectively targeting CSCs in CRC.
  • Further research is needed to optimize treatment combinations and overcome challenges in late-stage CRC.
  • Understanding CSC biology and immune interactions is key to developing effective therapies.
Keywords:
T cellscancercancer stem cellscell therapycolon cancer

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