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Identification and Dissection of Diverse Mouse Adipose Depots
Published on: July 11, 2019
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Diversity in Cell Morphology, Composition, and Function among Adipose Depots in River Buffaloes
Xintong Yang1, Ruirui Zhu1, Ziyi Song1
1State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Guangxi University, Nanning 530005, China.
International Journal of Molecular Sciences
|May 13, 2023
Summary
River buffaloes exhibit distinct fat deposition patterns. Subcutaneous adipose tissue (AT) shows larger cell size and extracellular matrix association, while visceral AT is linked to immunity, offering insights into fat regulation.
Area of Science:
- Animal Science
- Biochemistry
- Genomics
Background:
- Fat deposition is a key economic trait in livestock.
- Adipose tissues (ATs) in different depots have varying value and function.
- Understanding AT characteristics in river buffaloes is crucial for managing fat deposition.
Purpose of the Study:
- To characterize cell size, composition, and function of six adipose tissue depots in river buffaloes.
- To identify unique features of sternum subcutaneous AT and perirenal AT.
- To explore the developmental origins of AT depots in river buffaloes.
Main Methods:
- Comparative analysis of cell size and composition across six AT depots.
- Assessment of functional associations (e.g., extracellular matrix, immunity, FA oxidation).
- Analysis of HOX paralog expression to infer developmental origins.
Main Results:
- Subcutaneous AT depots have larger cell sizes than visceral AT depots.
- Subcutaneous AT is associated with the extracellular matrix; visceral AT with immunity.
- Sternum subcutaneous AT is unique due to high unsaturated fatty acids and metabolic protection roles.
- Perirenal AT is highly active in fatty acid oxidation.
- HOX paralog expression suggests variable origins of AT depots mediated by progenitor cells.
Conclusions:
- River buffalo AT depots possess distinct cellular, compositional, and functional features.
- Sternum subcutaneous AT and perirenal AT have specialized roles in metabolism and energy supply.
- The origin of AT depots in river buffaloes is likely influenced by progenitor cell heterogeneity.
