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Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis
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Author Spotlight: Unveiling the Pathway Linking Obesity to Autoimmune Inflammation in Multiple Sclerosis

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The Role of BDNF in Multiple Sclerosis Neuroinflammation

Viviana Nociti1,2, Marina Romozzi1

  • 1Institute of Neurology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy.

International Journal of Molecular Sciences
|May 13, 2023
PubMed

Insights

Inflammation in multiple sclerosis (MS) has dual effects. Brain-derived neurotrophic factor (BDNF) may offer neuroprotection by modulating neuroinflammation in MS.

Area of Science:

  • Neuroscience
  • Immunology
  • Neurology

Background:

  • Multiple sclerosis (MS) is a chronic central nervous system (CNS) disease characterized by inflammation.
  • Inflammation in MS can exert both beneficial and detrimental effects on disease pathogenesis.
  • Brain-derived neurotrophic factor (BDNF) is crucial for neuroplasticity and neuronal survival.

Purpose of the Study:

  • To review the multifaceted role of inflammation in multiple sclerosis.
  • To analyze the potential neuroprotective and neuro-modulatory functions of BDNF in MS.
  • To explore novel therapeutic strategies for MS based on the interplay between inflammation and BDNF.

Main Methods:

  • Literature review of existing studies on MS, neuroinflammation, and BDNF.
  • Analysis of the dual roles of inflammation in MS pathogenesis.
  • Exploration of BDNF's mechanisms in modulating neuroinflammation and providing neuroprotection.

Main Results:

  • Inflammation is a constant feature in MS, with complex effects on disease progression.
  • Immune cells, microglia, and astrocytes can release BDNF, suggesting a potential endogenous neuroprotective mechanism.
  • BDNF may play a role in mitigating neuroinflammation and promoting neuronal survival in MS.

Conclusions:

  • Understanding the intricate relationship between inflammation and BDNF is critical for MS research.
  • Targeting BDNF or modulating neuroinflammation holds promise for developing new MS therapies.
  • Further investigation into BDNF's role could lead to innovative therapeutic strategies for multiple sclerosis.
Keywords:
CNS inflammationMSbrain-derived neurotrophic factordemyelinating diseasesneuroprotectionneurotrophin

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