Related Experiment Video For acute hepatic porphyria
Updated: Jul 30, 2025
Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
Published on: July 31, 2016
Intrahepatic Cholangiocarcinoma and Acute Intermittent Porphyria: A Case Report
Claudio Carmine Guida1,2, Maria Nardella1,2, Leonardo Fiorentino3
1Interregional Reference Center for Porphyria, 71013 San Giovanni Rotondo, Italy.
Abstract:
Patients suffering from different forms of acute hepatic porphyria present a high risk of primary liver cancer, specifically hepatocellular carcinoma and cholangiocarcinoma, determined by the activity of the disease even though an exact mechanism of carcinogenesis has not been recognized yet. Here, we present the clinical case of a 72-year-old woman who, approximately 29 years after the diagnosis of acute intermittent porphyria, presented with intrahepatic cholangiocarcinoma with a histological diagnosis of adenocarcinoma starting from the biliary-pancreatic ducts, which was diagnosed during the clinical and anatomopathological evaluation of a pathological fracture of the femur.
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