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Serious Bacterial Infections in Preterm Infants: Should Their Age Be "Corrected"?
Mohamad Hadhud1, Itai Gross2,3, Noa Hurvitz1
1Department of Pediatrics, Hadassa-Hebrew University Medical Center, Hebrew University of Jerusalem, Jerusalem 91120, Israel.
Journal of Clinical Medicine
|May 13, 2023
Summary
Corrected age is crucial for assessing serious bacterial infections (SBI) in preterm infants. Preterm infants under 3 months corrected age show a higher SBI risk, similar to term infants, highlighting the need for age correction in fever assessments.
Area of Science:
- Neonatal Medicine
- Pediatric Infectious Diseases
- Neurodevelopmental Pediatrics
Background:
- Adjusting preterm infant age for neurodevelopmental assessments is standard practice.
- The validation of using corrected age for assessing serious bacterial infection (SBI) in preterm infants is limited.
- Accurate age assessment is critical, particularly for infants over 3 months chronological age but under 3 months corrected age.
Purpose of the Study:
- To evaluate the difference in serious bacterial infection (SBI) incidence in preterm infants based on chronological versus corrected age.
- To determine if corrected age impacts the risk assessment for SBI in preterm infants presenting with fever.
- To compare SBI risk in preterm infants with corrected age <3 months to that of term infants <3 months.
Main Methods:
- Retrospective analysis of pediatric emergency department (PED) presentations for 448 preterm infants born between 2010 and 2019.
- Inclusion criteria: preterm infants presenting with fever within their first year of life.
- Infants categorized into three groups based on chronological and corrected age: corrected age >3 months; chronological age >3 months/corrected age <3 months; chronological and corrected age <3 months.
Main Results:
- Serious bacterial infection (SBI) incidence was 2.6% in preterm infants with corrected age >3 months.
- SBI incidence was 16.7% in preterm infants with chronological age >3 months but corrected age <3 months.
- SBI incidence was 33.3% in preterm infants with both chronological and corrected age <3 months (p < 0.001).
- The control group of 300 term infants <3 months had an SBI incidence of 15.3%.
Conclusions:
- Preterm infants with a corrected age under 3 months face an elevated risk of serious bacterial infection (SBI).
- This increased risk is comparable to that observed in term infants under 3 months of age.
- Age correction is recommended for preterm infants presenting with fever to accurately assess SBI risk.
Keywords:
corrected ageemergency medicineex-premature infantspremature infantsserious bacterial infectionMore Related Videos
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