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Magnetic Particle Spectroscopy for Point-of-Care: A Review on Recent Advances
Parsa Yari1, Bahareh Rezaei1, Clifton Dey1
1Department of Electrical and Computer Engineering, Texas Tech University, Lubbock, TX 79409, USA.
Sensors (Basel, Switzerland)
|May 13, 2023
Summary
Magnetic particle spectroscopy (MPS) biosensors offer sensitive detection for various applications. MPS point-of-care devices are emerging as user-friendly, affordable tools for remote health monitoring.
Area of Science:
- Biosensing technologies
- Nanotechnology
- Biomedical engineering
Background:
- Magnetic particle spectroscopy (MPS)-based biosensors have advanced significantly since 2006.
- MPS platforms are utilized for diverse applications including disease diagnosis and pathogen detection.
- Multi-functional magnetic nanoparticles (MNPs) enhance MPS versatility for biomarker detection.
Purpose of the Study:
- To review different MPS platforms and their underlying theories and mechanisms.
- To analyze MPS applications in biomedical and biological fields.
- To discuss the potential and challenges of MPS point-of-care (POC) devices.
Main Methods:
- Review of dual-frequency and mono-frequency driving field designs in MPS.
- Analysis of MPS bioassay implementation based on volume or surface detection.
- Examination of surface-functionalized MNPs as nanoprobes for analyte binding.
Main Results:
- MPS platforms, particularly when combined with MNPs, demonstrate versatility in detecting numerous biomarkers.
- Significant applications of MPS in biomedical and biological fields have been identified.
- Emerging MPS point-of-care (POC) devices offer high sensitivity, simplicity, and low cost.
Conclusions:
- MPS POC devices are poised for widespread adoption due to their advantages and the rise of telemedicine.
- Opportunities and challenges exist for MPS POC devices in meeting the demand for rapid, affordable, and user-friendly diagnostics.
- Further development is needed to optimize MPS devices for home-based health assessments and remote monitoring.
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