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Published on: June 15, 2020
Histopathological analysis of vascular malformations
Calver Pang1,2, Jeries Abu-Hanna2, Chung Sim Lim1,2
1Department of Surgical Biotechnology, Division of Surgery & Interventional Science, Faculty of Medical Sciences, University College London, London, UK.
Insights
A new histopathological criteria was developed to improve the diagnosis of vascular malformations. This diagnostic aid significantly reduced discrepancies between clinical and histopathological findings, aiding treatment decisions.
Area of Science:
- Histopathology
- Vascular Malformations
- Diagnostic Criteria
Background:
- Accurate histopathological diagnosis of vascular malformations is critical for effective patient management.
- Existing diagnostic methods show significant discrepancies between clinical and histopathological assessments.
Purpose of the Study:
- To propose and develop a standardized histopathological criteria for diagnosing vascular malformations.
- To evaluate the efficacy of the proposed criteria in reducing diagnostic discrepancies.
Main Methods:
- A cohort of 18 patients with surgically resected vascular malformations was analyzed.
- A novel 10-parameter histopathological criteria was developed and applied.
- Discrepancies between initial and revised histopathological diagnoses were compared with clinical diagnoses.
Main Results:
- Initial histopathological diagnoses showed an 88.9% discrepancy with clinical diagnoses.
- Application of the proposed criteria reduced discrepancies to 38.9% after the first revision and 33.3% after the second revision.
- The developed criteria demonstrated a notable improvement in diagnostic accuracy.
Conclusions:
- Significant discrepancies between clinical and histopathological diagnoses of vascular malformations necessitate standardized diagnostic criteria.
- The proposed histopathological criteria can serve as a valuable guide for accurate diagnosis, improved treatment, and enhanced clinical practice.
Objective:
To propose and develop a histopathological criteria to help diagnose vascular malformations.
Methods:
All patients who underwent surgical resection and had a confirmed histopathological diagnosis of vascular malformations from 01 March 2018-26 February 2020 were included. A criteria based on 10 parameters was developed to help diagnose vascular malformations. Discrepancies between clinical and histopathological diagnosis were evaluated.
Results:
A total of 18 cases were identified. There was a discrepancy between the clinical diagnosis and the initially reported histopathological diagnosis in 16 cases (88.9%). This was reduced to 7 (38.9%) and 6 cases (33.3%) with first and second time revised histopathological analysis using proposed criteria.
Conclusions:
The discrepancy between clinical and histopathological diagnoses of vascular malformations has highlighted the requirement of an agreed criteria for histopathologists to help formulate their diagnosis. The proposed criteria may be used as a guide in addressing this and guide treatment and improve clinical practice.
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