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Chitosan-Based Smart Biomaterials for Biomedical Applications: Progress and Perspectives
Indra J Budiarso1, Novi D W Rini1, Annisa Tsalsabila2
1Materials Science and Engineering Research Group, Faculty of Mechanical and Aerospace Engineering, Institut Teknologi Bandung, Jl. Ganesha 10, Bandung 40132, West Java, Indonesia.
ACS Biomaterials Science & Engineering
|May 13, 2023
Summary
Chitosan, a versatile biopolymer, offers excellent properties for advanced biomaterials. Its unique structures, including nanoparticles and hydrogels, show promise in drug delivery, bone regeneration, wound healing, and dentistry.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Biomedical Engineering
Background:
- Smart and functional biomaterials are rapidly advancing, driven by the need for improved interactions with living systems.
- Chitosan is a promising biopolymer due to its biodegradability, hemostatic, antibacterial, antioxidant, and biocompatible properties.
- Its polycationic nature and reactive groups enable versatile modifications and structure formation.
Purpose of the Study:
- To review the development of chitosan-based smart biomaterials.
- To highlight versatile chitosan structures like nanoparticles, hydrogels, nanofibers, and films.
- To discuss their biomedical applications and strategies for performance enhancement.
Main Methods:
- Literature review of recent advancements in chitosan biomaterials.
- Analysis of chitosan's inherent properties and modification strategies.
- Compilation of applications in drug delivery, bone scaffolds, wound healing, and dentistry.
Main Results:
- Chitosan can be engineered into various smart biomaterial structures.
- These structures demonstrate significant potential in diverse biomedical fields.
- Performance enhancement strategies are crucial for targeted applications.
Conclusions:
- Chitosan is a key material for developing advanced, functional biomaterials.
- Its versatility supports innovation in drug delivery, tissue engineering, and regenerative medicine.
- Further research can optimize chitosan-based solutions for clinical use.
