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Chitosan-Based Smart Biomaterials for Biomedical Applications: Progress and Perspectives.

Indra J Budiarso1, Novi D W Rini1, Annisa Tsalsabila2

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Summary

Chitosan, a versatile biopolymer, offers excellent properties for advanced biomaterials. Its unique structures, including nanoparticles and hydrogels, show promise in drug delivery, bone regeneration, wound healing, and dentistry.

Keywords:
bone scaffoldchitosandentistrydrug deliverysmart biomaterialswound healing

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Biomedical Engineering

Background:

  • Smart and functional biomaterials are rapidly advancing, driven by the need for improved interactions with living systems.
  • Chitosan is a promising biopolymer due to its biodegradability, hemostatic, antibacterial, antioxidant, and biocompatible properties.
  • Its polycationic nature and reactive groups enable versatile modifications and structure formation.

Purpose of the Study:

  • To review the development of chitosan-based smart biomaterials.
  • To highlight versatile chitosan structures like nanoparticles, hydrogels, nanofibers, and films.
  • To discuss their biomedical applications and strategies for performance enhancement.

Main Methods:

  • Literature review of recent advancements in chitosan biomaterials.
  • Analysis of chitosan's inherent properties and modification strategies.
  • Compilation of applications in drug delivery, bone scaffolds, wound healing, and dentistry.

Main Results:

  • Chitosan can be engineered into various smart biomaterial structures.
  • These structures demonstrate significant potential in diverse biomedical fields.
  • Performance enhancement strategies are crucial for targeted applications.

Conclusions:

  • Chitosan is a key material for developing advanced, functional biomaterials.
  • Its versatility supports innovation in drug delivery, tissue engineering, and regenerative medicine.
  • Further research can optimize chitosan-based solutions for clinical use.