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Mpox and HIV: a Narrative Review.
Carlos S Saldana1, Colleen F Kelley2, Bruce M Aldred2
1Division of Infectious Diseases, Emory University School of Medicine, Ponce de Leon Center, 341 Ponce de Leon Ave NE, Atlanta, GA, 30308, USA. cssalda@emory.edu.
Current HIV/AIDS Reports
|May 13, 2023
Summary
People with HIV (PWH) experienced disproportionate mpox impacts during the 2022 outbreak. While some PWH had mild mpox, others faced severe disease, necessitating further research into effective treatments and prevention strategies.
Area of Science:
- Infectious Diseases
- Virology
- Public Health
Background:
- The 2022 mpox outbreak disproportionately affected People with HIV (PWH).
- Mpox presentation, management, and prognosis can differ significantly in PWH, particularly those with advanced HIV disease.
Purpose of the Study:
- To review the literature on mpox in PWH.
- To highlight special considerations for mpox infection in PWH, including epidemiology, clinical presentation, diagnostics, treatment, prevention, and public health messaging.
Main Methods:
- Literature review of available studies on mpox in People with HIV.
Main Results:
- Mpox can range from mild to severe in PWH, with variations based on HIV control (viremia, CD4 count).
- Severe mpox in PWH may present with necrotic lesions, mucosal involvement, and systemic complications, leading to higher healthcare utilization.
- Supportive care and antiviral drugs are used for severe mpox in PWH, but clinical trial data are lacking.
Conclusions:
- PWH require special considerations for mpox management.
- Further research, including randomized clinical trials, is needed to optimize therapeutic and preventive strategies for mpox in PWH.
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