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Cancer in pathologically confirmed multiple system atrophy.

William P Cheshire1, Shunsuke Koga2, Philip W Tipton3

  • 1Division of Autonomic Disorders, Department of Neurology, Mayo Clinic, 4500 San Pablo Rd., Jacksonville, FL, 32224, USA. cheshire@mayo.edu.

Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society
|May 13, 2023
PubMed
Summary
This summary is machine-generated.

This study found no increased cancer risk in patients with multiple system atrophy (MSA). Research on synuclein in cancer may offer future therapeutic insights for MSA patients.

Keywords:
Alpha-synucleinBreast neoplasmsGamma-synucleinMultiple system atrophy

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Area of Science:

  • Neuroscience
  • Oncology
  • Pathology

Background:

  • Multiple system atrophy (MSA) is characterized by α-synuclein aggregation.
  • γ-synuclein, a related protein, is linked to invasive cancers.
  • A potential clinical association between MSA and cancer requires investigation.

Purpose of the Study:

  • To determine if cancer occurs with increased frequency in individuals with MSA.
  • To investigate a potential clinical association between MSA and various cancers, including breast cancer.

Main Methods:

  • Retrospective review of medical records for 269 pathologically confirmed MSA patients (1998-2022).
  • Comparison with an equal number of age- and sex-matched controls.
  • Querying personal and family cancer histories; comparing age-adjusted breast cancer rates with US population data.

Main Results:

  • No significant difference in personal cancer history between MSA patients (37/269) and controls (45/269).
  • Similar rates of parental and sibling cancer history between groups.
  • Age-adjusted breast cancer rate in MSA (0.83%) was not significantly different from controls (0.67%), though lower than the US population (2.0%).

Conclusions:

  • This retrospective study found no significant clinical association between MSA and breast or other cancers.
  • Further research into synuclein pathology in cancer may reveal future therapeutic targets for MSA.