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Assembly and Characterization of Biomolecular Memristors Consisting of Ion Channel-doped Lipid Membranes
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An Aqueous Electrolyte Gated Artificial Synapse with Synaptic Plasticity Selectively Mediated by Biomolecules
Xinzhao Xu1, Haoqin Zhang1, Lin Shao1
1Department of Materials Science, Fudan University, Shanghai, 200433, P. R. China.
Angewandte Chemie (International Ed. in English)
|May 13, 2023
Summary
This study introduces a novel artificial synapse using organic electrochemical transistors that selectively responds to glucose. This breakthrough paves the way for biomolecule-mediated artificial neural networks in biomedical applications.
Area of Science:
- Biomedical Engineering
- Neuroscience
- Materials Science
Background:
- Artificial neural networks (ANNs) are inspired by biological synapses for biomedical interfaces.
- Existing artificial synapses lack selective response to non-electroactive biomolecules and direct operation in biological settings.
Purpose of the Study:
- To develop an artificial synapse capable of selective biomolecule response.
- To investigate glucose-modulated synaptic plasticity in organic electrochemical transistors.
Main Methods:
- Utilized organic electrochemical transistors to create an artificial synapse.
- Investigated the enzymatic reaction of glucose and glucose oxidase for modulation.
- Assessed device performance in blood serum with varying glucose concentrations.
Main Results:
- Achieved selective modulation of synaptic plasticity by glucose via enzymatic reaction.
- Demonstrated long-term channel conductance modulation mimicking synaptic weight changes.
- Observed enhanced synaptic behaviors in blood serum at higher glucose levels.
Conclusions:
- The developed artificial synapse shows potential for in vivo applications as artificial neurons.
- This work advances ANNs with biomolecule-mediated synaptic plasticity for neuro-prosthetics and human-machine interfaces.
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