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Updated: Jul 30, 2025
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Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples
Published on: October 2, 2020
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Long non-coding RNAs in breast cancer stem cells
Yuting Huang1,2, Wenju Mo2, Xiaowen Ding3
1Department of Oncology, Wenzhou Medical University, Wenzhou, 325035, China.
Medical Oncology (Northwood, London, England)
|May 13, 2023
Summary
Long non-coding RNAs (lncRNAs) play a crucial role in breast cancer stem cell (BCSC) development and progression. Understanding lncRNA mechanisms in BCSCs offers potential for new breast cancer biomarkers and therapies.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Breast cancer is a heterogeneous disease with high recurrence and mortality rates.
- Breast cancer stem cells (BCSCs) drive metastasis and recurrence.
- Long non-coding RNAs (lncRNAs) are increasingly implicated in cancer progression.
Purpose of the Study:
- To review the role of lncRNAs in tumor occurrence and progression via BCSCs.
- To discuss the molecular mechanisms regulating BCSC stemness.
- To explore lncRNAs as biomarkers and therapeutic targets for breast cancer.
Main Methods:
- Literature review of recent studies on lncRNAs and BCSCs.
- Analysis of lncRNA expression and function in breast cancer.
- Discussion of molecular pathways involved in BCSC regulation.
Main Results:
- Abnormal lncRNA expression is observed in BCSCs.
- lncRNAs significantly impact breast cancer occurrence, progression, invasion, and metastasis.
- lncRNAs are involved in regulating BCSC self-renewal and differentiation.
Conclusions:
- lncRNAs are critical regulators of BCSC stemness and breast cancer progression.
- lncRNAs hold promise as biomarkers for breast cancer progression.
- Targeting lncRNAs may offer novel therapeutic strategies for breast cancer treatment.
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