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Related Concept Videos

Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

777
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
777

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Degradable Temperature-Sensitive Hydrogel Loaded with Heparin Effectively Prevents Post-Operative Tissue Adhesions.

Puxin Lang1, Tiantian Liu1, Shiqi Huang1

  • 1College of Polymer Science and Engineering, Sichuan University, Chengdu, Sichuan 610000, China.

ACS Biomaterials Science & Engineering
|May 14, 2023
PubMed
Summary

This study developed a novel carboxymethyl chitosan-poloxamer hydrogel (PCHgel) to prevent post-surgical tissue adhesions. PCHgel effectively reduced adhesions in rats, showing promise for clinical use.

Keywords:
Poloxamer338anti-adhesioncarboxymethyl chitosanheparintemperature-sensitive hydrogel

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Surgical Innovation

Background:

  • Post-surgical tissue adhesions are a significant clinical problem, potentially causing severe complications.
  • Current treatments lack ideal properties like spreadability, degradability, and self-healing capabilities.
  • Medical hydrogels offer a promising approach as physical barriers to prevent tissue adhesion at surgical sites.

Purpose of the Study:

  • To develop and evaluate a novel carboxymethyl chitosan-poloxamer-heparin composite hydrogel (PCHgel) for preventing tissue adhesions.
  • To assess the spreadability, degradability, self-healing properties, and mechanical strength of the PCHgel.
  • To investigate the efficacy and safety of PCHgel in reducing tissue adhesions in a preclinical model.

Main Methods:

  • Formulation of poloxamer-based hydrogels incorporating carboxymethyl chitosan (CMCS) and heparin.
  • Characterization of hydrogel properties including viscosity, mechanical strength, self-healing, and degradation.
  • In vivo evaluation of PCHgel's efficacy in reducing tissue adhesions in a rat model.
  • Assessment of the adhesion suppression mechanism and biosafety of the PCHgel.

Main Results:

  • The PCHgel exhibited low viscosity below 20 °C, transforming into a gel at body temperature upon application.
  • The composite hydrogel demonstrated stable, self-healable barrier formation with sustained heparin release and degradation over ~14 days.
  • PCHgel significantly reduced tissue adhesions in rats, outperforming hydrogels without heparin.
  • The study confirmed the adhesion suppression mechanism and demonstrated good biosafety of PCHgel.

Conclusions:

  • PCHgel is a promising injectable, self-healing hydrogel for preventing post-surgical tissue adhesions.
  • The combination of CMCS and heparin in a poloxamer base enhances anti-adhesion efficacy and biocompatibility.
  • PCHgel demonstrates significant clinical potential due to its high efficacy, safety, and ease of use.