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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Nano-crosslinked dynamic hydrogels for biomedical applications.

Qinghe Wang1, Yan Zhang2, Yue Ma2

  • 1Institute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu, 212013, PR China.

Materials Today. Bio
|May 14, 2023
PubMed
Summary
This summary is machine-generated.

Nano-crosslinked dynamic hydrogels integrate nanomaterials into hydrogels, enhancing mechanical properties and enabling stimuli-responsive functions for advanced biomedical applications. These versatile materials offer improved biocompatibility and therapeutic potential.

Keywords:
Dynamic hydrogelsNano-crosslinkingReversible covalent bondsSelf-healingTissue engineering

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Materials Chemistry

Background:

  • Hydrogels mimic natural extracellular matrices, widely used in biomedical fields.
  • Dynamic hydrogels offer injectability and self-healing properties.
  • Nano-crosslinked dynamic hydrogels combine advantages of both hydrogels and nanomaterials.

Purpose of the Study:

  • To review the fabrication and applications of nano-crosslinked dynamic hydrogels.
  • To discuss various nanomaterials used as crosslinkers.
  • To highlight the benefits and potential of these advanced hydrogels in medicine.

Main Methods:

  • Incorporation of nanomaterials (metals, oxides, nanoclays, carbon-based, BP, polymers, liposomes) as crosslinkers.
  • Utilizing reversible covalent and physical crosslinking strategies.
  • Reviewing fabrication techniques and characterization of nano-crosslinked hydrogels.

Main Results:

  • Enhanced mechanical properties (strength, injectability, shear-thinning) of hydrogels.
  • Development of stimuli-responsive (pH, heat, light) and functional hydrogels (photothermal, antimicrobial, regenerative).
  • Reduced potential cytotoxicity of nanomaterials and excellent biocompatibility promoting cell functions.

Conclusions:

  • Nano-crosslinked dynamic hydrogels offer significant advantages for biomedical applications.
  • Versatile fabrication strategies allow for tailored material properties and functions.
  • These hydrogels show great promise for tissue repair, regeneration, and drug delivery.