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Published on: February 14, 2014
Association between selenium intake and cognitive function among older adults in the US: National Health and
Khondoker Adeba Ferdous1, Linda L Knol1, Han-A Park1
1Department of Human Nutrition and Hospitality Management, College of Human Environmental Sciences, The University of Alabama, PO Box 870311, Tuscaloosa, AL 35487, USA.
Abstract:
Cognitive decline occurs commonly as people age. Despite the complexity of cellular mechanisms, oxidative stress is a critical contributor to age-associated cognitive impairment. Selenium plays an important role in antioxidant defense systems. The purpose of the present study was to assess the correlation between selenium intake and cognitive function among older adults. The participants were individuals ≥65 years old (n=1681) who participated in the 2011-2014 National Health and Nutrition Examination Survey (NHANES), a country-wide cross-sectional survey. Dietary selenium intake and adequacy were evaluated with 2 d of 24-h recalls and the estimated average requirement (EAR) cut-point method, respectively. Cognitive function was assessed with the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) score, which was significantly higher when selenium intake was adequate. After adjusting for energy intake, the association was no longer significant. Inadequate intake of selenium is rare in the US and dependent on caloric intake in older adults.
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