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Related Concept Videos

Radiological Investigation II: MRI and Ventilation Perfusion Scan01:30

Radiological Investigation II: MRI and Ventilation Perfusion Scan

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Description
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...
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Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
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Related Experiment Video

Updated: Jul 30, 2025

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function
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Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function

Published on: April 12, 2024

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Functional lung imaging using novel and emerging MRI techniques.

Chuan T Foo1,2, David Langton2,3, Bruce R Thompson4

  • 1Department of Respiratory Medicine, Eastern Health, Melbourne, VIC, Australia.

Frontiers in Medicine
|May 14, 2023
PubMed
Summary
This summary is machine-generated.

New MRI techniques offer sensitive, non-invasive lung evaluation for respiratory diseases. Hyperpolarized gas MRI and other novel methods provide crucial functional and microstructural lung imaging data.

Keywords:
fluorinated gashyperpolarized gasmagnetic resonance imagingoxygen-enhancedperfusionphased-resolved functional lung imagingtechniqueventilation heterogeneity

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Area of Science:

  • Pulmonary Medicine
  • Medical Imaging
  • Radiology

Background:

  • Respiratory diseases are a major global cause of death and disability.
  • Early diagnosis is crucial but hindered by a lack of sensitive, non-invasive tools.
  • Computed tomography (CT) provides structural lung imaging but lacks functional data and involves radiation.

Purpose of the Study:

  • To review novel contrast and non-contrast Magnetic Resonance Imaging (MRI) techniques for lung evaluation.
  • To discuss the clinical applications of these emerging lung imaging modalities in disease.

Main Methods:

  • Review of hyperpolarized gas MRI, fluorinated gas MRI, oxygen-enhanced MRI, Fourier decomposition MRI, and phase-resolved functional lung imaging.
  • Focus on overcoming historical challenges of lung MRI (short T2, low proton density).

Main Results:

  • Hyperpolarized gas MRI enables functional and microstructural lung evaluation.
  • Other novel MRI techniques show potential for interrogating lung function.
  • These methods offer alternatives to CT, providing functional insights without significant radiation.

Conclusions:

  • Emerging MRI techniques, particularly hyperpolarized gas MRI, are poised to significantly advance the functional and microstructural assessment of lung diseases.
  • These non-invasive methods offer promising clinical applications for improved diagnosis and management of respiratory conditions.