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[Severe osteopenia in young children with hyperthyroidism. 2 cases].

J Léger, P Czernichow, M Garabédian

    Archives Francaises De Pediatrie
    |February 1, 1986
    PubMed
    Summary

    Grave's disease in children can cause severe bone loss, leading to fractures. Monitoring bone health is crucial for young patients with hyperthyroidism.

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    Area of Science:

    • Pediatric Endocrinology
    • Metabolic Bone Disease

    Background:

    • Grave's disease, an autoimmune disorder, commonly affects adults but can occur in children.
    • Hyperthyroidism in children can impact growth and development, including bone metabolism.
    • Severe bone demineralization is an unusual complication in pediatric Grave's disease.

    Observation:

    • Two young children with Grave's disease presented with significant bone demineralization.
    • One child experienced a spontaneous fracture and vertebral collapse.
    • Biochemical analysis revealed decreased 25-hydroxyvitamin D (25(OH)D) with normal calcitriol (1,25-(OH)2D) and 24,25-dihydroxyvitamin D levels, alongside elevated alkaline phosphatase.

    Findings:

    • The observed bone demineralization and associated complications are not previously documented in young hyperthyroid children.
    • This suggests a potential link between altered vitamin D metabolism and bone health in pediatric Grave's disease.
    • Elevated alkaline phosphatase indicates increased bone turnover.

    Implications:

    • Pediatric Grave's disease warrants careful evaluation for bone demineralization.
    • Bone X-rays and assessment of calcium and phosphorus metabolism should be routine for affected children.
    • Early detection and management of bone complications can prevent severe skeletal issues.

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