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Therapeutic targeting of anoikis resistance in cutaneous melanoma metastasis

Hannah M Neuendorf1,2, Jacinta L Simmons1,2,3, Glen M Boyle1,2,3

  • 1Cancer Drug Mechanisms Group, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.

Frontiers in Cell and Developmental Biology
|May 14, 2023
PubMed

Insights

Anoikis resistance is crucial for melanoma cell survival and metastasis. Targeting this resistance with inhibitors may prevent melanoma spread and improve patient outcomes.

Area of Science:

  • Oncology
  • Cell Biology
  • Cancer Metastasis

Background:

  • Anoikis, or cell death upon detachment, is a barrier to tumor cell dissemination.
  • Melanoma cells must overcome anoikis to survive and form metastases.
  • Understanding anoikis resistance mechanisms is key to preventing melanoma spread.

Purpose of the Study:

  • To review inhibitors targeting anoikis resistance in melanoma.
  • To explore therapeutic strategies for preventing melanoma metastasis initiation.
  • To identify potential treatments for circulating tumor cells (CTCs).

Main Methods:

  • Literature review of intracellular signaling cascades in anoikis resistance.
  • Analysis of small molecule, peptide, and antibody inhibitors.
  • Exploration of therapeutic repurposing for melanoma treatment.

Main Results:

  • Several intracellular signaling pathways contribute to anoikis resistance in melanoma.
  • Various inhibitors targeting these pathways have been identified.
  • These inhibitors show potential for repurposing to prevent melanoma metastasis.

Conclusions:

  • Targeting anoikis resistance is a promising therapeutic strategy for melanoma.
  • Inhibitors of anoikis resistance may prevent the initiation of metastatic lesions.
  • Repurposing existing drugs could offer new avenues for melanoma treatment and improved patient prognosis.
Keywords:
anoikismelanomametastasisrepurposingtargetingtherapy

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