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Updated: Jul 30, 2025

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
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Isolated cerebellar infarction in a case of JAK 2 mutation-negative polycythemia vera: A case report

Prasad Krishnan1

  • 1Department of Neurosurgery, National Neurosciences Centre, Kolkata, West Bengal, India.

Brain Circulation
|May 14, 2023
PubMed

Polycythemia vera is a myeloproliferative disorder caused by clonal expansion of erythroid precursors in the bone marrow commonly due to a mutation in the Janus kinase 2 (JAK2) gene located in the short arm of chromosome 9. Hyperviscosity of blood due to high hematocrit causes a low flow state that may predispose to infarct. These commonly occur in the supratentorial compartment. The case of a 46-year-old man who had an isolated cerebellar infarct with high hematocrit and hemoglobin levels and low serum erythropoietin levels is described. Further investigations eventually led to the unmasking of a JAK2 mutation-negative polycythemia vera.

Keywords:
CerebellumInfarctionJAK 2 mutationLow flow infarctionPolycythemia vera

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