Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Canine mucosal antrectomy.

J M Becker, C B Rosen, K A Kelly

    Archives of Surgery (Chicago, Ill. : 1960)
    |July 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Canadian Surgery Forum.

    Canadian journal of surgery. Journal canadien de chirurgie·2022
    Same author

    Liver Allograft Provides Immunoprotection for the Cardiac Allograft in Combined Heart-Liver Transplantation.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2016
    Same author

    Living donor liver transplantation in emergencies: is it time to say yes?

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2015
    Same author

    What is the better surgical technique in ileal pouch-anal anastomosis? Mucosectomy.

    Inflammatory bowel diseases·2013
    Same author

    Is pouchitis a systemic manifestation of inflammatory bowel disease?

    Inflammatory bowel diseases·2013
    Same author

    Combined liver transplantation and gastric sleeve resection for patients with medically complicated obesity and end-stage liver disease.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2012
    Same journal

    The White Test: A New Dye Test for Intraoperative Detection of Bile Leakage During Major Liver Resection-Invited Critique.

    Archives of surgery (Chicago, Ill. : 1960)·2017
    Same journal

    Use of Vascular Clamping in Hepatic Surgery: Lessons Learned From 1260 Liver Resections-Invited Critique.

    Archives of surgery (Chicago, Ill. : 1960)·2017
    Same journal

    Randomized Clinical Trial of Small-Incision and Laparoscopic Cholecystectomy in Patients With Symptomatic Cholecystolithiasis: Primary and Clinical Outcomes-Invited Critique.

    Archives of surgery (Chicago, Ill. : 1960)·2017
    Same journal

    Liver Resection With a New Multiprobe Bipolar Radiofrequency Device-Invited Critique.

    Archives of surgery (Chicago, Ill. : 1960)·2017
    Same journal

    Porcine and Bovine Surgical Products: Jewish, Muslim, and Hindu Perspectives-Invited Critique.

    Archives of surgery (Chicago, Ill. : 1960)·2017
    Same journal

    Neuroendocrine Liver Metastasis: Transplant as Part of Multimodality Liver-Directed Therapy-Reply.

    Archives of surgery (Chicago, Ill. : 1960)·2016
    See all related articles

    Mucosal antrectomy temporarily reduced serum gastrin and gastric acid secretion in dogs. However, G cell hyperplasia and neogenesis counteracted these effects, indicating incomplete long-term reduction.

    Area of Science:

    • Gastroenterology
    • Surgical Research
    • Endocrinology

    Background:

    • Gastrin plays a key role in regulating gastric acid secretion.
    • Antrectomy, a surgical procedure, aims to reduce gastrin levels and acid production.
    • Understanding the long-term effects of antrectomy on gastrin regulation is crucial for surgical outcomes.

    Purpose of the Study:

    • To investigate the impact of mucosal antrectomy on postprandial serum gastrin and gastric acid secretion.
    • To evaluate the compensatory mechanisms, such as G cell hyperplasia and neogenesis, following mucosal antrectomy.

    Main Methods:

    • Surgical antrectomy was performed on dogs with and without proximal gastric vagotomy.
    • Serum gastrin levels and gastric acid output were measured before and after the procedure.

    Related Experiment Videos

  • Gastrin and G cell presence in mucosal tissue was assessed post-antrectomy.

    • Main Results:

    • Mucosal antrectomy significantly decreased integrated postprandial serum gastrin response and hydrochloric acid output.
    • These reductions were temporary in some dogs, with decreases lasting less than 7 hours.
    • Increased mucosal gastrin levels and the presence of G cells in transferred corporal mucosa were observed post-antrectomy.

    Conclusions:

    • Mucosal antrectomy effectively reduces serum gastrin and gastric acid secretion in the short term.
    • Hyperplasia of residual G cells and G-cell neogenesis can counteract the effects of antrectomy.
    • These compensatory mechanisms limit the long-term efficacy of mucosal antrectomy in controlling gastrin and acid secretion.