[Effect of bacterial lipopolysaccharide pyrogenal on the development of the Syrian hamster embryo]

Pyrogenal is injected to female hamsters (Mesocricetus auratus) at various time of pregnancy twice, with a 24 hour's interval: at first 100 or 50, and then--50 or 25 minimal pyrogenic doses. The embryos are examined on the 15th day of the intrauterine development by means of main teratologic methods. Pyrogenal injected on the 9th--10th day of the embryonal development produces hydrocephaly, micrognathia, retardation in development, hemorrhagic syndrome. Pyrogenal injected during some other time of pregnancy produces hemolysis of erythrocytes. This is proved by presence of hemosiderin in the foetal liver.