Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Allergic Reactions

Allergic Reactions

Hypersensitivities

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...

Allergic Drug Reactions

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...

Cross-reactivity

Cross-reactivity

Asthma-I: Introduction

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

Vaccinations

Vaccinations

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same authorSame journal

Multiple Antibiotic Allergy Evaluation Strategy (MAAES): A Comparative Effectiveness Study.

The journal of allergy and clinical immunology. In practice·2026

Same authorSame journal

Anaphylaxis Clinical Care Pathway: Incorporating Intranasal Epinephrine (Adrenaline).

The journal of allergy and clinical immunology. In practice·2026

Same author

Editorial for French expert recommendations by Societe Francaise d' Anesthesie et de Reanimation and the Societe Francaise d'Allergologie "Diagnosis and management of perioperative immediate hypersensitivity reactions - 2025": Updated SFAR and SFA guidelines on the Diagnosis and Management of perioperative immediate hypersensitivity.

Anaesthesia, critical care & pain medicine·2026

Same author

Reported safety events from ultrasound enhancing agents: a critical reappraisal.

Echo research and practice·2026

Same author

Alpha-Gal Syndrome: Unrecognized Risks of a Tick-Bite-Associated Allergy in Transplantation and Cellular Therapy.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026

Same author

Evaluation of anaphylactic reactions involving carboplatin and paclitaxel reported to the FDA from 1970 to 2023.

Gynecologic oncology reports·2026

Search research articles

Related Experiment Video

Updated: Jul 30, 2025

Measuring Local Anaphylaxis in Mice

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

Identifying and Managing Those at Risk for Vaccine-Related Allergy and Anaphylaxis.

Cosby A Stone¹, Lene H Garvey², Shuaib Nasser³

¹Center for Drug Safety and Immunology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tenn.

The Journal of Allergy and Clinical Immunology. in Practice

|May 14, 2023

Summary

Immediate hypersensitivity reactions to vaccines, including anaphylaxis, are rare. This review examines new mRNA vaccine knowledge alongside established vaccine reaction data for diagnosis and management.

Keywords:

Anaphylaxis Complement Excipient Hypersensitivity ISRR Immediate Vaccine

More Related Videos

Antigenic Liposomes for Generation of Disease-specific Antibodies

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

Intralymphatic Immunotherapy and Vaccination in Mice

Intralymphatic Immunotherapy and Vaccination in Mice

Published on: February 2, 2014

Related Experiment Videos

Last Updated: Jul 30, 2025

Measuring Local Anaphylaxis in Mice

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

Antigenic Liposomes for Generation of Disease-specific Antibodies

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

Intralymphatic Immunotherapy and Vaccination in Mice

Intralymphatic Immunotherapy and Vaccination in Mice

Published on: February 2, 2014

Area of Science:

Immunology
Vaccinology
Public Health

Background:

Immediate hypersensitivity reactions, including anaphylaxis, are rare vaccine side effects.
Understanding these reactions is crucial for vaccine safety and public trust.

Conclusions:

Safe evaluation and management strategies are essential for vaccine programs.
Distinguishing immune-mediated from non-immune stress responses is key.
Continued research into vaccine reaction mechanisms is vital.