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Updated: Jul 30, 2025

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence
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Published on: January 7, 2019

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Regulatory network and targeted interventions for CCDC family in tumor pathogenesis

Zhen Liu1, Weiwei Yan1, Shaohua Liu2

  • 1Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, 510315, Guangzhou, China.

Cancer Letters
|May 14, 2023
PubMed

Insights

Coiled-coil domain-containing (CCDC) genes are implicated in various diseases and cancer. This review explores their role in tumor pathogenesis and potential as therapeutic targets.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Coiled-coil domain-containing (CCDC) proteins are crucial in cellular functions, including signal transduction.
  • Dysregulation of CCDC genes is linked to diseases like primary ciliary dyskinesia, infertility, and various cancers.
  • CCDC genes influence malignant tumor cell behaviors such as growth, invasion, metastasis, and chemosensitivity.

Purpose of the Study:

  • To review the involvement of CCDC family genes in tumor pathogenesis.
  • To elucidate the upstream and downstream molecular mechanisms associated with CCDC genes in cancer.
  • To summarize the potential of CCDC family genes as therapeutic targets in oncology.

Main Methods:

  • Literature review of studies on CCDC genes in cancer.
  • Analysis of molecular mechanisms regulating CCDC gene expression and function.
  • Synthesis of data on CCDC gene involvement in tumor progression and treatment response.

Main Results:

  • CCDC genes play significant roles in the development and progression of diverse cancers.
  • Specific CCDC genes are associated with key oncogenic processes, including tumor growth, invasion, and metastasis.
  • Alterations in CCDC gene expression, mutations, and methylation patterns are common in various malignancies.

Conclusions:

  • CCDC family genes are critical regulators in tumor pathogenesis.
  • Understanding CCDC gene functions offers insights into cancer development.
  • CCDC genes represent promising therapeutic targets for cancer treatment.
Keywords:
CCDC familyCoiled-coil domain-containingFusion geneInhibitorTherapeutic target

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