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Prevalence of intracranial aneurysms in Marfan syndrome

David J Laczynski1, Siwei Dong1, Vidyasagar Kalahasti2

  • 1Cleveland Clinic Foundation, Department of Vascular Surgery, Cleveland, OH.

Journal of Vascular Surgery
|May 14, 2023
PubMed
Abstract

Insights

The prevalence of intracranial aneurysms (IA) in Marfan syndrome (MFS) patients was 7.1%. This study found no significant association between IA and patient or aortic characteristics in MFS. Further research is needed to confirm these findings.

Area of Science:

  • Neurology
  • Cardiology
  • Genetics

Background:

  • Aortic aneurysms are common in Marfan syndrome (MFS).
  • The prevalence of intracranial aneurysms (IA) in MFS is not well-established.
  • There is ongoing debate regarding an association between MFS and IA.

Purpose of the Study:

  • To determine the prevalence of intracranial aneurysms (IA) in patients with Marfan syndrome (MFS).
  • To investigate potential associations between IA and patient or aortic characteristics in MFS.

Main Methods:

  • Retrospective review of 983 patients with MFS between 1995 and 2021.
  • Identified 198 patients who underwent intracranial imaging (CTA and/or MRA).
  • Collected data on aneurysm details, patient demographics, and aortic characteristics.

Main Results:

  • The prevalence of IA in the MFS population studied was 7.1% (14/198).
  • No significant differences in age or aortic characteristics were found between patients with and without IA.
  • The most common IA location was the internal carotid artery; no ruptures were reported.

Conclusions:

  • Intracranial aneurysms (IA) were identified in 7.1% of Marfan syndrome (MFS) patients studied.
  • No significant patient or aortic factors were associated with IA, though small sample size may limit findings.
  • Multi-institutional studies are necessary to accurately define IA risk in MFS and guide screening recommendations.
Keywords:
AortaIntracranial aneurysmMarfan syndrome

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