Cyclodextrin regulated natural polysaccharide hydrogels for biomedical applications-a review

Area of Science:

• Biomaterials Science
• Polymer Chemistry
• Nanotechnology

Background:

• Natural polysaccharide hydrogels (NPHs) are widely used in biomedicine due to biocompatibility and biodegradability.
• Conventional NPHs often suffer from poor mechanical properties and unpredictable gelation.
• Cyclodextrins (CDs) are versatile building blocks for creating functional biomaterials.

Purpose of the Study:

• To systematically review the construction, classification, and biomedical applications of CD-regulated natural polysaccharide hydrogels (CD-NPHs).
• To provide a comprehensive overview of CD-NPHs from a material science perspective for biomedical fields.
• To discuss current challenges and future prospects of CD-NPHs in biomedicine.

Main Methods:

• Literature review focusing on CD-NPHs synthesis and characterization.
• Analysis of CD-NPHs classification based on structural and functional properties.
• Evaluation of CD-NPHs applications in drug delivery, wound dressing, cell encapsulation, and tissue engineering.

Main Results:

• CD-NPHs exhibit improved mechanical strength and controlled gelation compared to conventional NPHs.
• CD-NPHs maintain excellent biocompatibility and biodegradability.
• CD-NPHs demonstrate significant potential in various biomedical applications, including advanced drug delivery systems and tissue regeneration scaffolds.

Conclusions:

• CD-NPHs represent a promising class of advanced biomaterials with enhanced properties for biomedical applications.
• Further research into CD-NPHs will facilitate their translation from laboratory to clinical practice.
• This review provides a foundational understanding for developing novel CD-NPHs-based therapies.