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Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia
07:46

Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia

Published on: May 9, 2013

Pathophysiology and Optimal Treatment of Intracranial Branch Atheromatous Disease

Ichiro Deguchi1, Shinichi Takahashi1

  • 1Department of Neurology and Cerebrovascular Medicine, Saitama Medical University International Medical Center.

Journal of Atherosclerosis and Thrombosis
|May 14, 2023
PubMed

Insights

Branch atheromatous disease (BAD) is a difficult-to-treat stroke subtype. Current treatments for other strokes do not prevent BAD progression, highlighting the need for effective therapies.

Area of Science:

  • Neurology
  • Cerebrovascular Disease
  • Atherosclerosis

Background:

  • Intracranial branch atheromatous disease (BAD) involves occlusion of large perforating arteries by atherosclerotic plaque and thrombus.
  • BAD is characterized by progressive worsening, particularly motor paralysis, and is refractory to standard stroke treatments.
  • Existing treatments for atherothrombotic and lacunar infarction do not prevent BAD progression, impacting functional prognosis.

Conclusions:

  • Optimal treatment methods for BAD are urgently needed due to its refractory nature and poor prognosis.
  • Further research and clinical trials are essential to develop effective interventions for BAD.
  • Addressing BAD is critical for improving outcomes in complex cerebral infarction cases.

Keywords:
AlteplaseBranch atheromatous diseaseDual-antiplatelet treatmentLenticulostriate artery

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