Related Experiment Video

Updated: Jul 17, 2026

Visualization and Analysis of Blood Flow and Oxygen Consumption in Hepatic Microcirculation: Application to an Acute Hepatitis Model
10:40

Visualization and Analysis of Blood Flow and Oxygen Consumption in Hepatic Microcirculation: Application to an Acute Hepatitis Model

Published on: August 5, 2012

Acute Liver Failure Secondary to Anthocyanidin Use-A Case Report

Débora Puzzi Fernandes1, Elaine Cristina De Ataide1, Simone Reges Perales1

  • 1Liver Transplant Unit, University of Campinas, Campinas, São Paulo, Brazil.

Transplantation Proceedings
|May 14, 2023
PubMed

Insights

This case report details a patient who developed acute liver failure (ALF) after using Morosil, a red orange extract. The patient successfully underwent liver transplantation, highlighting a rare adverse event associated with this supplement.

Area of Science:

  • Hepatology
  • Toxicology
  • Nutraceuticals

Background:

  • Drug-induced liver injury is a significant cause of acute liver failure (ALF).
  • Morosil, derived from red oranges, is recognized for its antioxidant properties and use in managing metabolic and cardiovascular conditions.
  • The potential for idiosyncratic reactions to supplements necessitates careful monitoring.

Observation:

  • A 37-year-old female presented with grade 4 hepatic encephalopathy following 30 days of Morosil use.
  • Symptoms including jaundice and altered bowel habits emerged two weeks after initiating Morosil.
  • The patient's condition met the diagnostic criteria for ALF.

Findings:

  • Morosil use was identified as the likely cause of acute liver failure in this patient.
  • The patient's high Model for End-Stage Liver Disease (MELD) score of 41 indicated severe liver dysfunction.
  • Diagnosis of ALF was confirmed using established clinical criteria.

Implications:

  • This case highlights a rare instance of acute liver failure potentially linked to Morosil consumption.
  • It underscores the importance of considering supplement-induced liver injury in unexplained ALF cases.
  • Further research into the hepatotoxicity of Citrus extracts like Morosil is warranted.

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