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Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit
Published on: August 2, 2017
Hippocampal rotation is associated with ventricular atrial size
Matthew T Whitehead1,2,3,4,5,6, Catherine Limperopoulos7,8,9, Sarah D Schlatterer7,8,9
1Department of Neuroradiology, Children's National Hospital, Washington, DC, USA. WhiteheadM@CHOP.edu.
Pediatric Radiology
|May 14, 2023
Summary
Fetal ventriculomegaly, a condition causing parental concern, is linked to incomplete hippocampal inversion. Larger fetal ventricular size increases the likelihood of this inversion anomaly.
Area of Science:
- Neuroimaging
- Fetal Development
- Pediatric Neurology
Background:
- Fetal ventriculomegaly causes parental anxiety and diagnostic uncertainty.
- Accurate prenatal counseling requires understanding its causes and associated findings.
- A novel association between ventriculomegaly and incomplete hippocampal inversion has been observed.
Purpose of the Study:
- To investigate the relationship between fetal ventricular size and incomplete hippocampal inversion.
Main Methods:
- Retrospective review of prenatal and postnatal brain MRIs in normal subjects and patients with isolated ventriculomegaly.
- Evaluation of lateral ventricular diameter and hippocampal inversion markers.
- Documentation of intraventricular hemorrhage.
Main Results:
- A significant association was found between incomplete hippocampal inversion and ventricular size in both normal and ventriculomegaly groups.
- Severe ventriculomegaly correlated with adverse postnatal outcomes.
- Larger fetal ventricular size increased the odds of incomplete hippocampal inversion.
Conclusions:
- Lateral ventricular atrial diameter and incomplete hippocampal inversion are associated.
- Reduced hippocampal inversion correlates with larger ventricular atria.
- Increased fetal ventricular size is a risk factor for incomplete hippocampal inversion.
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